Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Todd County is a Western Kentucky agricultural county centered on Elkton. Dark-fired tobacco, grain farming, and proximity to Hopkinsville and Clarksville make it an affordable option for farmland buyers.