Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Simpson County sits on the Tennessee border centered on Franklin. Its location on I-65 between Bowling Green and Nashville creates unique economic opportunity, with affordable farmland and growing commercial development.