Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Discover authentic Appalachian living in Owsley County, an Eastern Kentucky treasure with Booneville as its county seat. Home to a small population of just over 4,400, this county offers rugged, heavily wooded land, perfect for those seeking ultimate privacy, self-sufficiency, and a connection to unspoiled natural beauty.