Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Madison County is a Bluegrass county centered on Richmond and home to Eastern Kentucky University. Rich agricultural land, proximity to Lexington, and a mix of suburban growth and rural character define the area.