Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. The Eastern Kentucky county of Leslie, with Hyden as its seat and a population of about 10,120, is characterized by its deep hollows and forested mountains, presenting a unique opportunity for land buyers looking for remote, unspoiled terrain ideal for off-grid living and self-sufficiency.