Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Lawrence County, located in Eastern Kentucky with its seat in Louisa and a population near 15,313, boasts scenic beauty along the Big Sandy River and abundant natural resources, making it an attractive option for land buyers interested in peaceful rural living and outdoor pursuits.