Fayette County is home to Lexington, Kentucky's second-largest city and the heart of the Bluegrass Region. Known for horse farms, rolling pastures, and strong land values, Fayette County offers urban amenities alongside agricultural heritage. County seat: Lexington. Explore affordable acreage in Fulton County, located in Kentucky's Western region and seat of Hickman. Boasting a modest population of 5,969, this county is perfect for homesteaders and investors drawn to its fertile bottomlands, abundant waterfowl, and tranquil, rural lifestyle along the Mississippi River.